Nolvadex (tamoxifen citrate) is very similar to Clomid in their manner of action and function. It behaves in the same manner in all tissues, and is a mixed estrogen agonist/antagonist of the same type as Clomid. These are not only same in function, but also similar in structure. To say that Nolvadex is responsible for reducing the levels of estrogens is not correct, but The fact is that, it blocks the estrogens from the receptors as an antagonist, makes the tissues to do nothing. Nolvadex is not an anabolic steroid but it is responsible to manage or minimize the side effects caused by steroids. It is commonly said that Nolvadex is reducing the gains, is a theory with no facts and it should not take such claims seriously. The real situation is, a large no of bodybuilders have made excellent muscle and body gains through the use of Nolvadex. Probably, the belief of reducing gains by the use of Nolvadex came from the fact that the scientific literature reports slight decrease in IGF-1 1 (individuals using anabolic steroids were not studied though) from use of Nolvadex. On the base of this study, Dan Duchene opines that Nolvadex decreases gains. However, if any effect stays, that is very slight and not very much noticeable to show or describe. It is also a fact that no such activity of reducing gains has been observed by using clomid as these are similar drugs in structure and function. The experienced bodybuilders use clomid and Nolvadex without the fear of reduction in gains achieved through the use of anabolic steroids as they know the real thing about it. If there is any literature with such claim, that may be their biased claim. The fact is that Nolvadex decrease water retention, which is desirable activity, but the latter approach is not based on fact.